IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity

Nat Neurosci. 2006 Aug;9(8):993-5. doi: 10.1038/nn1742. Epub 2006 Jul 16.

Abstract

How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and an siRNA targeting the insulin-like growth factor-1 (IGF-1) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3-kinase (PI3k)-Cdc42 pathway by the IGF-1 receptor, but not by the TrkA or TrkB receptors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Polarity*
  • Cells, Cultured
  • Hippocampus / cytology*
  • Neurons / cytology*
  • Neurons / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / metabolism
  • Rats
  • Receptor, IGF Type 1 / genetics
  • Receptor, IGF Type 1 / metabolism*
  • Receptor, trkA / metabolism
  • Receptor, trkB / metabolism
  • cdc42 GTP-Binding Protein / metabolism

Substances

  • RNA, Small Interfering
  • Phosphatidylinositol 3-Kinases
  • Receptor, IGF Type 1
  • Receptor, trkA
  • Receptor, trkB
  • cdc42 GTP-Binding Protein