Microwave-assisted synthesis of 3,1,2- and 2,1,8-Re(I) and 99mTc(I)-metallocarborane complexes

Andrew E C Green; Patrick W Causey; Anika S Louie; Andrea F Armstrong; Laura E Harrington; John F Valliant

doi:10.1021/ic0605928

Microwave-assisted synthesis of 3,1,2- and 2,1,8-Re(I) and 99mTc(I)-metallocarborane complexes

Inorg Chem. 2006 Jul 24;45(15):5727-9. doi: 10.1021/ic0605928.

Authors

Andrew E C Green¹, Patrick W Causey, Anika S Louie, Andrea F Armstrong, Laura E Harrington, John F Valliant

Affiliation

¹ Departments of Chemistry and Medical Physics & Applied Radiation Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4M1.

PMID: 16841972
DOI: 10.1021/ic0605928

Abstract

Microwave heating was used to prepare eta5-rhenium carborane complexes in aqueous reaction media. For carboranes bearing sterically demanding substituents, isomerization of the cage from 3,1,2 to 2,1,8 derivatives occurred concomitantly with complexation. Microwave heating was equally effective at the tracer level using technetium-99m, affording access to a new class of synthons for designing novel molecular imaging agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbon / chemistry*
Chemistry / methods*
Metals / chemistry
Microwaves*
Models, Chemical
Molecular Conformation
Organotechnetium Compounds / chemical synthesis*
Organotechnetium Compounds / chemistry
Radiopharmaceuticals / chemical synthesis*
Radiopharmaceuticals / chemistry
Rhenium / chemistry*
Technetium / chemistry*

Substances

Metals
Organotechnetium Compounds
Radiopharmaceuticals
Rhenium
Technetium
Carbon