Abstract
The effects of CD34 mobilization with chemotherapy and G-CSF administration were evaluated in 13 HIV-positive patients with relapsed lymphomas and low CD4 counts. After mobilization, CD4+ cells increased significantly while HIV-RNA and integrated HIV-DNA showed no increases. G-CSF led to an increase of CD4+ cells with limited effects on HIV replication.
MeSH terms
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Adult
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Aged
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Antigens, CD34 / drug effects
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Antigens, CD34 / immunology*
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Blood Cell Count
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CD4-CD8 Ratio
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Granulocyte Colony-Stimulating Factor / administration & dosage
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HIV Infections / complications
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HIV Infections / immunology*
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HIV Infections / virology
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Hematopoietic Stem Cell Mobilization*
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Humans
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Lymphoma, AIDS-Related / drug therapy
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Lymphoma, AIDS-Related / immunology*
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Lymphoma, AIDS-Related / virology*
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Middle Aged
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Proviruses / drug effects
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RNA, Viral / analysis
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RNA, Viral / blood
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Recurrence
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Treatment Outcome
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Virus Replication / drug effects
Substances
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Antigens, CD34
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RNA, Viral
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Granulocyte Colony-Stimulating Factor