Ample evidence from functional magnetic resonance imaging studies has demonstrated functional brain asymmetries in the motor cortex and cerebellum within the task of finger-to-thumb (intratask), but the asymmetries across left and right hand-performed tasks of finger-to-thumb (intertask) are little known. Here, we found that intratask evoked asymmetry responses in the motor cortex and cerebellum, and interestingly in the Extra-Nuclear and insula. Intertask comparisons between left and right hand-activated images and between the asymmetries of intratasks of left and right hand, however, revealed distinct lateralization responses in the temporal cortex, extranuclear, parahippocampal gyrus, cingulate gyrus and prominently in basal ganglia. These results suggest that multiple aspects of functional asymmetries in motor organization are reflected in specific brain regions.