Abstract
The effect of iontophoretic application of the 5-HT3 receptor agonist, phenylbiguanide (PBG), on the excitation of the trigeminal spinal nucleus oralis (TSNO) neurons to tooth-pulp (TP) stimulation was examined. The PBG application inhibited the TP-evoked TSNO neuronal excitation, and this inhibition was completely blocked by co-application of a GABAA receptor antagonist, bicuculline. The results suggest that the activation of 5-HT3 receptors elicits GABA release in the TSNO.
MeSH terms
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Action Potentials / drug effects
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Action Potentials / physiology
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Animals
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Bicuculline / pharmacology
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Biguanides / pharmacology
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Dental Pulp / innervation*
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Dose-Response Relationship, Drug
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Drug Interactions
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GABA Antagonists / pharmacology
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Indoles / pharmacology
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Interneurons / drug effects
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Interneurons / physiology*
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Iontophoresis / methods
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Male
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Rats
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Rats, Wistar
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Receptors, Serotonin, 5-HT3 / physiology*
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Serotonin Antagonists / pharmacology
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Serotonin Receptor Agonists / pharmacology
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Trigeminal Nucleus, Spinal / cytology*
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Tropisetron
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gamma-Aminobutyric Acid / metabolism*
Substances
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Biguanides
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GABA Antagonists
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Indoles
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Receptors, Serotonin, 5-HT3
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Serotonin Antagonists
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Serotonin Receptor Agonists
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gamma-Aminobutyric Acid
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Tropisetron
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phenyl biguanide
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Bicuculline