Abstract
[Structure: see text] The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against Plasmodium falciparum and demonstrated attenuated antimalarial activity relative to that of manzamine A.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemical synthesis*
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Antimalarials / isolation & purification
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Antimalarials / pharmacology*
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Carbazoles / chemical synthesis*
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Carbazoles / isolation & purification
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Carbazoles / pharmacology*
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Chloroquine / pharmacology
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Drug Resistance / drug effects
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Molecular Structure
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Plasmodium falciparum / drug effects*
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Porifera / chemistry
Substances
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Antimalarials
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Carbazoles
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manzamine A
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Chloroquine