Dual-action acid/base- and base/acid-controllable molecular switch

Ming-Liang Yen; Wan-Sheung Li; Chien-Chen Lai; Ito Chao; Sheng-Hsien Chiu

doi:10.1021/ol060988n

Dual-action acid/base- and base/acid-controllable molecular switch

Org Lett. 2006 Jul 20;8(15):3223-6. doi: 10.1021/ol060988n.

Authors

Ming-Liang Yen¹, Wan-Sheung Li, Chien-Chen Lai, Ito Chao, Sheng-Hsien Chiu

Affiliation

¹ Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, and Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan, R.O.C.

PMID: 16836371
DOI: 10.1021/ol060988n

Abstract

[Structure: see text] We report a molecular switch that not only can be switched between its complexed and decomplexed states through the sequential addition of an acid and a base (NH4+ and Proton Sponge, respectively) but also can be operated equally through the sequential addition of basic and acidic reagents (Et2NH and TFA, respectively).