The period immediately after breaking alcohol for alcohol dependent patients is marked by several pathologies troubles like withdrawal syndrome. Taking charge therapeutic of withdrawal is made to limit the severity of this withdrawal syndrome to prevent complications and guarantee a transition toward an accompaniment in abstinence. An attitude based on measuring the withdrawal syndrome and risk factors is effective to limit eventual complications. The detoxification can be realised in ambulatory or in hospital depending on different modes, with specifies indications for hospitalization. The patient preference intervenes often in the mode of choice for the method. An attentive surveillance clinical, benzodiazepine, hydration and vitamin therapy are essential for good alcohol withdrawal.