Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferating

Breast Cancer Res. 2006;8(4):106. doi: 10.1186/bcr1520.

Abstract

Recent genetic and cell biological studies illustrate the importance of active transforming growth factor-beta signaling in preventing the proliferation of estrogen receptor-positive cells in the normal mammary gland, and suggest how the loss of this inhibition may be important in early breast cancer progression.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Breast / cytology
  • Breast / metabolism*
  • Cattle
  • Cell Proliferation
  • Disease Models, Animal
  • Epithelial Cells / physiology*
  • Estrogen Receptor alpha / physiology*
  • Female
  • Humans
  • Mammary Glands, Animal / cytology
  • Mammary Glands, Animal / metabolism*
  • Mice
  • Rats
  • Transforming Growth Factor beta / biosynthesis*

Substances

  • Estrogen Receptor alpha
  • Transforming Growth Factor beta