Abstract
Recent genetic and cell biological studies illustrate the importance of active transforming growth factor-beta signaling in preventing the proliferation of estrogen receptor-positive cells in the normal mammary gland, and suggest how the loss of this inhibition may be important in early breast cancer progression.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Breast / cytology
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Breast / metabolism*
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Cattle
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Cell Proliferation
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Disease Models, Animal
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Epithelial Cells / physiology*
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Estrogen Receptor alpha / physiology*
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Female
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Humans
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Mammary Glands, Animal / cytology
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Mammary Glands, Animal / metabolism*
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Mice
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Rats
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Transforming Growth Factor beta / biosynthesis*
Substances
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Estrogen Receptor alpha
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Transforming Growth Factor beta