Synthesis of furo-salicylanilides and their heterocyclic derivatives with anticipated molluscicidal activity

Arch Pharm (Weinheim). 2006 Aug;339(8):448-55. doi: 10.1002/ardp.200600020.

Abstract

The synthesis of new furo-salicylanilides and their heterocyclic derivatives is described. Twenty-three compounds were screened for their molluscicidal activity against Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni. Five of the tested compounds showed no activity, while eighteen compounds showed strong to moderate activity using bayluscide as a reference.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Biomphalaria / drug effects
  • Biomphalaria / growth & development
  • Dose-Response Relationship, Drug
  • Furans / chemical synthesis*
  • Furans / toxicity
  • Molecular Structure
  • Molluscacides / chemical synthesis*
  • Molluscacides / toxicity*
  • Niclosamide / standards
  • Niclosamide / toxicity
  • Salicylanilides / chemical synthesis*
  • Salicylanilides / toxicity
  • Schistosoma mansoni / drug effects
  • Schistosoma mansoni / growth & development
  • Solubility
  • Structure-Activity Relationship
  • Toxicity Tests / methods

Substances

  • Furans
  • Molluscacides
  • Salicylanilides
  • Niclosamide