Biphasic anaphylactic reaction to Ketorolac tromethamine

Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):449-50. doi: 10.1177/039463200601900223.

Abstract

Ketorolac tromethamine is a recent injectable non-steroidal anti-inflammatory drug (NSAID) with analgesic properties approved for short-term pain management. In spite of its increasing use both in adults and children, relatively few allergic-like reactions have been reported. Reactions are often severe, and a death occurred following an intramuscular injection of ketorolac.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anaphylaxis / drug therapy
  • Anaphylaxis / physiopathology*
  • Anti-Inflammatory Agents / therapeutic use
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Chlorpheniramine / therapeutic use
  • Drug Hypersensitivity / drug therapy
  • Drug Hypersensitivity / physiopathology*
  • Female
  • Histamine H1 Antagonists / therapeutic use
  • Humans
  • Ketorolac Tromethamine / adverse effects*
  • Methylprednisolone / therapeutic use
  • Skin Tests
  • Urticaria / etiology

Substances

  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Histamine H1 Antagonists
  • Chlorpheniramine
  • Ketorolac Tromethamine
  • Methylprednisolone