Prevalence and antifungal susceptibility of yeasts obtained from the oral cavity of elderly individuals

Mycopathologia. 2006 Jul;162(1):39-44. doi: 10.1007/s11046-006-0029-6.

Abstract

Infections caused by Candida yeasts are common in elderly individuals. Seventy-five isolates of Candida spp. were obtained from saliva samples of 136 institutionalized elderly individuals resident in six retirement homes of Belo Horizonte, Brazil. Forty-seven isolates (62.66%) were identified as Candida albicans, 15 (20%) as C. tropicalis, 7 (9.33%) as C. glabrata, 4 (5.33) as C. parapsilosis, and 2 (2.67%) as C. guilliermondii. Among the 136 elderly individuals studied, 49 (36%) were male and 87 (64%) were female. Ages ranged from 60 to 90 years old. Sixty-three (46.3%) of the institutionalized individuals were denture wearers and, among them, 53 (84.1%) carried Candida yeasts in the oral cavity. Forty-four subjects presented lesions in the oral mucosa and among these, 36 (82%), had positive culture for Candida spp. The samples were tested for the in vitro susceptibility to amphotericin B, itraconazole, fluconazole and 5-flucytosin, and great variations were observed in the minimum inhibitory concentrations (MIC) of these drugs according to the species.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antifungal Agents / pharmacology*
  • Antifungal Agents / therapeutic use
  • Brazil / epidemiology
  • Candida / drug effects*
  • Candida / isolation & purification*
  • Candidiasis, Oral / drug therapy
  • Candidiasis, Oral / epidemiology*
  • Candidiasis, Oral / microbiology*
  • Dentures / adverse effects
  • Drug Resistance, Fungal
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Prevalence

Substances

  • Antifungal Agents