beta-Glucosidase inhibitory activities of phenylpropanoid glycosides, vanicoside A and B from Polygonum sachalinense rhizome

Y Kawai; H Kumagai; H Kurihara; K Yamazaki; R Sawano; N Inoue

doi:10.1016/j.fitote.2006.05.008

beta-Glucosidase inhibitory activities of phenylpropanoid glycosides, vanicoside A and B from Polygonum sachalinense rhizome

Fitoterapia. 2006 Sep;77(6):456-9. doi: 10.1016/j.fitote.2006.05.008. Epub 2006 May 24.

Authors

Y Kawai¹, H Kumagai, H Kurihara, K Yamazaki, R Sawano, N Inoue

Affiliation

¹ Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan. kawai@fish.hokudai.ac.jp

PMID: 16828242
DOI: 10.1016/j.fitote.2006.05.008

Abstract

The phenylpropanoid glycosides, vanicoside A and B, isolated from rhizomes of giant knotweed (Polygonum sachalinense) showed beta-glucosidase inhibitory activity, with IC(50) values of 59.8 and 48.3 mug/ml (59.9 and 50.5 muM), respectively. In contrast, p-coumaric acid and ferulic acid, corresponding to phenylpropanoyl moieties of vanicosides, exhibited very little inhibition.

MeSH terms

Cinnamates / administration & dosage
Cinnamates / pharmacology*
Cinnamates / therapeutic use
Enzyme Inhibitors / administration & dosage
Enzyme Inhibitors / pharmacology*
Enzyme Inhibitors / therapeutic use
Glycosides / administration & dosage
Glycosides / pharmacology
Glycosides / therapeutic use
Humans
Inhibitory Concentration 50
Phytotherapy*
Plant Extracts / administration & dosage
Plant Extracts / pharmacology
Plant Extracts / therapeutic use
Polygonum*
Rhizome
beta-Glucosidase / antagonists & inhibitors*

Substances

Cinnamates
Enzyme Inhibitors
Glycosides
Plant Extracts
vanicoside B
vanicoside A
beta-Glucosidase