Solution equilibrium characterization of insulin-mimetic Zn(II) complexes

T Jakusch; K Gajda-Schrantz; Y Adachi; H Sakurai; T Kiss; L Horváth

doi:10.1016/j.jinorgbio.2006.05.003

Solution equilibrium characterization of insulin-mimetic Zn(II) complexes

J Inorg Biochem. 2006 Sep;100(9):1521-6. doi: 10.1016/j.jinorgbio.2006.05.003. Epub 2006 May 27.

Authors

T Jakusch¹, K Gajda-Schrantz, Y Adachi, H Sakurai, T Kiss, L Horváth

Affiliation

¹ Bioinorganic Chemistry Research Group of the Hungarian Academy of Sciences, University of Szeged, P.O. Box 440, H-6701 Szeged, Hungary.

PMID: 16824606
DOI: 10.1016/j.jinorgbio.2006.05.003

Abstract

Solution speciation (stoichiometry and stability constants) of the insulin mimetic Zn(II) complexes of several bidentate ligands with (O,O), (N,O) or (S,O) coordination modes have been determined by pH-metry at 25 degrees Celsius and I=0.2M (KCl). All ligands were found to coordinate in a bidentate way forming mono, bis and tris complexes, besides a mixed hydroxo bis complex ZnL(2)(OH) detected in the slightly basic pH range together with the tris complex. Relationships between the stability data, lipophilicity of the complexes and earlier biological data are evaluated. The validity of the linear free energy relationships (LFER) between the proton and Zn(II) complexes and also between the VO(IV) and Zn(II) complexes is tested.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hydrogen-Ion Concentration
Insulin / chemistry*
Molecular Structure
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry
Zinc / chemistry*

Substances

Insulin
Organometallic Compounds
Zinc