Studies on antiparasitic agents: effect of the lactam nucleus substitution in the 2-position on the in-vitro activity of new 5-nitroimidazoles

P Vanelle; J Maldonado; M Gasquet; F Delmas; P Timon-David; O Jentzer; M P Crozet

doi:10.1111/j.2042-7158.1991.tb03470.x

Studies on antiparasitic agents: effect of the lactam nucleus substitution in the 2-position on the in-vitro activity of new 5-nitroimidazoles

J Pharm Pharmacol. 1991 Oct;43(10):735-6. doi: 10.1111/j.2042-7158.1991.tb03470.x.

Authors

P Vanelle¹, J Maldonado, M Gasquet, F Delmas, P Timon-David, O Jentzer, M P Crozet

Affiliation

¹ Laboratoire de Chimie Organique, Faculté de Pharmacie, Marseille, France.

PMID: 1682453
DOI: 10.1111/j.2042-7158.1991.tb03470.x

Abstract

The in-vitro antiprotozoal activity of a series of new 5-nitroimidazoles substituted in the 2-position via a lactam nucleus was studied. All these compounds exhibited a better effect than metronidazole and structure-activity relationships are discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiprotozoal Agents / pharmacology*
Entamoeba histolytica / drug effects
Nitroimidazoles / pharmacology*
Structure-Activity Relationship

Substances

Antiprotozoal Agents
Nitroimidazoles