New antimycobacterial 2,3-dihydro-1-alkylindole-2-thiones

Folia Microbiol (Praha). 2006;51(1):25-6. doi: 10.1007/BF02931445.

Abstract

A series of 2,3-dihydroindole-2-thiones was evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. fortuitum, two strains of M. intracellulare and three strains of M. avium. 2,3-Dihydro-1-methyl-2-thioxoindole-3-one and 2,3-dihydro-1-butyl-2-thioxoindole-3-one were the most active substances against potentially pathogenic strains, being more active than isoniazide.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antitubercular Agents / pharmacology*
  • Indoles / chemistry
  • Indoles / pharmacology*
  • Isoniazid / pharmacology
  • Microbial Sensitivity Tests
  • Mycobacterium avium Complex / drug effects
  • Mycobacterium fortuitum / drug effects
  • Mycobacterium kansasii / drug effects
  • Mycobacterium tuberculosis / drug effects*
  • Nontuberculous Mycobacteria / drug effects*
  • Thiones / chemistry
  • Thiones / pharmacology*

Substances

  • 2,3-dihydro-1-butyl-2-thioxoindole-3-one
  • 2,3-dihydro-1-methyl-2-thioxoindole-3-one
  • Anti-Bacterial Agents
  • Antitubercular Agents
  • Indoles
  • Thiones
  • Isoniazid