Abstract
A series of 2,3-dihydroindole-2-thiones was evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. fortuitum, two strains of M. intracellulare and three strains of M. avium. 2,3-Dihydro-1-methyl-2-thioxoindole-3-one and 2,3-dihydro-1-butyl-2-thioxoindole-3-one were the most active substances against potentially pathogenic strains, being more active than isoniazide.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antitubercular Agents / pharmacology*
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Indoles / chemistry
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Indoles / pharmacology*
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Isoniazid / pharmacology
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Microbial Sensitivity Tests
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Mycobacterium avium Complex / drug effects
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Mycobacterium fortuitum / drug effects
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Mycobacterium kansasii / drug effects
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Mycobacterium tuberculosis / drug effects*
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Nontuberculous Mycobacteria / drug effects*
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Thiones / chemistry
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Thiones / pharmacology*
Substances
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2,3-dihydro-1-butyl-2-thioxoindole-3-one
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2,3-dihydro-1-methyl-2-thioxoindole-3-one
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Anti-Bacterial Agents
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Antitubercular Agents
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Indoles
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Thiones
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Isoniazid