Abstract
Some new tetrahydropyrimidine-2-thione, octahydroquinazoline-2-thione and thiazolo[3,2-a]pyrimidine derivatives have been synthesized and tested for their antihypertensive activity. Among them, compounds 1 and 2b can be considered more potent than the reference, nifedipine (CAS 21829-25-4), while compounds 3b and 10a are equipotent to it. In addition, compound 6 showed significant antihypertensive activity.
MeSH terms
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Animals
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Antihypertensive Agents / chemical synthesis*
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Antihypertensive Agents / pharmacology*
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Blood Pressure / drug effects
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Desoxycorticosterone
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Hypertension / chemically induced
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Hypertension / drug therapy
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Indicators and Reagents
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Male
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology*
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Rats
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Rats, Sprague-Dawley
Substances
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1,2,3,4-tetrahydropyrimidine-2-thione
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Antihypertensive Agents
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Indicators and Reagents
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Pyrimidines
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Desoxycorticosterone