Synthesis and evaluation of some 1,2,3,4-tetrahydropyrimidine-2-thione and condensed pyrimidine derivatives as potential antihypertensive agents

Arzneimittelforschung. 2006;56(5):322-7. doi: 10.1055/s-0031-1296729.

Abstract

Some new tetrahydropyrimidine-2-thione, octahydroquinazoline-2-thione and thiazolo[3,2-a]pyrimidine derivatives have been synthesized and tested for their antihypertensive activity. Among them, compounds 1 and 2b can be considered more potent than the reference, nifedipine (CAS 21829-25-4), while compounds 3b and 10a are equipotent to it. In addition, compound 6 showed significant antihypertensive activity.

MeSH terms

  • Animals
  • Antihypertensive Agents / chemical synthesis*
  • Antihypertensive Agents / pharmacology*
  • Blood Pressure / drug effects
  • Desoxycorticosterone
  • Hypertension / chemically induced
  • Hypertension / drug therapy
  • Indicators and Reagents
  • Male
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / pharmacology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • 1,2,3,4-tetrahydropyrimidine-2-thione
  • Antihypertensive Agents
  • Indicators and Reagents
  • Pyrimidines
  • Desoxycorticosterone