The identification of new protein kinase inhibitors as targets in modern drug discovery

Irini Akritopoulou-Zanze

The identification of new protein kinase inhibitors as targets in modern drug discovery

IDrugs. 2006 Jul;9(7):481-7.

Author

Irini Akritopoulou-Zanze¹

Affiliation

¹ Abbott Laboratories, Department 4CP, Building AP10-1, 100 Abbott Park Road, Abbott Park, IL 60064-6099, USA. irini.zanze@abbott.com

PMID: 16821161

Abstract

In recent years there has been great interest in developing protein kinase inhibitors as therapeutic agents for a variety of diseases. This article provides an overview on the history, development and validity of kinases as drug targets, as well as a description of kinase research, including its limitations, challenges and successes.

Publication types

Historical Article
Review

MeSH terms

Catalytic Domain
Diabetes Mellitus / drug therapy
Drug Design*
History, 20th Century
History, 21st Century
Humans
Inflammation / drug therapy
Molecular Structure
Neoplasms / drug therapy
Nervous System Diseases / drug therapy
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / history
Protein Kinase Inhibitors / isolation & purification*
Protein Kinases / chemistry

Substances

Protein Kinase Inhibitors
Protein Kinases