Effects of neonatal bilateral eye enucleation on postnatal development of the monoamines in posterior thalamus of the rat

J Neural Transm Gen Sect. 1991;85(3):231-42. doi: 10.1007/BF01244948.

Abstract

Levels of dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (serotonin, 5-HT) and their metabolites, and the activities of tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH) and monoamine oxidase A and B (MAO-A and MAO-B) have been determined in the rat posterior thalamus after enucleation during postnatal development. DA and 5-HT turnover rate have been measured as 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) accumulation rates after central decarboxylase inhibition by 3-hydroxybenzylhydrazine (NSD-1015). The major changes were an increase in noradrenergic and serotoninergic metabolism in enucleated animals compared with control animals. A decrease of the MAO-A to MAO-B ratio during postnatal development was found.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5-Hydroxytryptophan / metabolism
  • Aging / metabolism
  • Animals
  • Animals, Newborn / physiology*
  • Aromatic Amino Acid Decarboxylase Inhibitors
  • Aromatic-L-Amino-Acid Decarboxylases / metabolism
  • Biogenic Monoamines / metabolism*
  • Dihydroxyphenylalanine / metabolism
  • Dopamine / metabolism
  • Eye Enucleation*
  • Hydrazines / pharmacology
  • Male
  • Monoamine Oxidase / metabolism
  • Norepinephrine / metabolism
  • Rats
  • Rats, Inbred Strains
  • Serotonin / metabolism
  • Thalamus / growth & development*
  • Thalamus / metabolism
  • Tryptophan Hydroxylase / metabolism
  • Tyrosine 3-Monooxygenase / metabolism

Substances

  • Aromatic Amino Acid Decarboxylase Inhibitors
  • Biogenic Monoamines
  • Hydrazines
  • Serotonin
  • Dihydroxyphenylalanine
  • 3-hydroxybenzylhydrazine
  • 5-Hydroxytryptophan
  • Tyrosine 3-Monooxygenase
  • Tryptophan Hydroxylase
  • Monoamine Oxidase
  • Aromatic-L-Amino-Acid Decarboxylases
  • Dopamine
  • Norepinephrine