Neurotrophins and dementia--keeping in touch

Neuron. 2006 Jul 6;51(1):1-3. doi: 10.1016/j.neuron.2006.06.019.

Abstract

Down's syndrome patients develop dementia similar to Alzheimer's disease and show elevated levels of amyloid precursor protein in brain. Two papers in this issue of Neuron show that reduced retrograde transport or signaling of the neurotrophins NGF or BDNF, respectively, may account for the neuronal pathology in mouse models of Down's syndrome.

Publication types

  • Comment
  • Review

MeSH terms

  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / physiopathology*
  • Amyloid beta-Protein Precursor / genetics
  • Amyloid beta-Protein Precursor / metabolism*
  • Animals
  • Axonal Transport
  • Brain / metabolism
  • Brain / pathology
  • Brain / physiopathology*
  • Cell Death / genetics
  • Disease Models, Animal
  • Down Syndrome / genetics
  • Down Syndrome / metabolism
  • Down Syndrome / physiopathology*
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Mice
  • Nerve Growth Factors / genetics
  • Nerve Growth Factors / metabolism*
  • Neural Pathways / metabolism
  • Neural Pathways / pathology
  • Neural Pathways / physiopathology
  • Receptors, Nerve Growth Factor / genetics
  • Receptors, Nerve Growth Factor / metabolism

Substances

  • Amyloid beta-Protein Precursor
  • Nerve Growth Factors
  • Receptors, Nerve Growth Factor