Set shifting deficits in melancholic vs. non-melancholic depression: preliminary findings

I Michopoulos; I M Zervas; V M Papakosta; E Tsaltas; C Papageorgiou; T Manessi; Y G Papakostas; L Lykouras; C R Soldatos

doi:10.1016/j.eurpsy.2006.03.008

Set shifting deficits in melancholic vs. non-melancholic depression: preliminary findings

Eur Psychiatry. 2006 Sep;21(6):361-3. doi: 10.1016/j.eurpsy.2006.03.008. Epub 2006 Jul 11.

Authors

I Michopoulos¹, I M Zervas, V M Papakosta, E Tsaltas, C Papageorgiou, T Manessi, Y G Papakostas, L Lykouras, C R Soldatos

Affiliation

¹ 2nd Department of Psychiatry, Athens University Medical School, Attikon General Hospital, 1 Rimini Street, 124 62 Athens, Greece. panpsyclin@attikonhospital.gr

PMID: 16814993
DOI: 10.1016/j.eurpsy.2006.03.008

Abstract

Twenty-two patients with major depressive disorder, 11 of them with melancholic features, and 11 controls were investigated with CANTAB subtests focusing in visual memory/learning and executive functions. Melancholic patients performed worse than the other groups in all tasks and manifested a significant impairment in set shifting. The results are discussed in association with prefrontal dysfunction.

MeSH terms

Cognition Disorders / diagnosis
Cognition Disorders / epidemiology*
Demography
Depressive Disorder, Major / diagnosis
Depressive Disorder, Major / epidemiology*
Depressive Disorder, Major / psychology*
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Learning Disabilities / diagnosis
Learning Disabilities / epidemiology*
Male
Memory Disorders / diagnosis
Memory Disorders / epidemiology*
Middle Aged
Neuropsychological Tests
Prevalence
Severity of Illness Index
Surveys and Questionnaires