Abstract
A new 24-membered ring lactone, macrolactin N, was isolated from a culture broth of Bacillus subtilis and its structure was established by various spectral analysis. Macrolactin N inhibited Staphylococcus aureus peptide deformylase with an IC50 value of 7.5 microM and also showed antibacterial activity against Escherichia coli and S. aureus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amidohydrolases / antagonists & inhibitors*
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Amidohydrolases / metabolism
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Bacillus subtilis / chemistry*
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Bacillus subtilis / metabolism
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Macrolides / chemistry*
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Macrolides / metabolism
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Macrolides / pharmacology*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Protease Inhibitors / chemistry*
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Protease Inhibitors / metabolism
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Protease Inhibitors / pharmacology*
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / enzymology
Substances
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Anti-Bacterial Agents
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Macrolides
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Protease Inhibitors
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macrolactin N
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Amidohydrolases
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peptide deformylase