Intrinsic macrolide resistance of the Mycobacterium tuberculosis complex is inducible

Antimicrob Agents Chemother. 2006 Jul;50(7):2560-2. doi: 10.1128/AAC.00264-06.

Abstract

Mycobacterium tuberculosis is intrinsically resistant to macrolides, a characteristic associated with expression of the erm(37) gene. This intrinsic resistance was found to be inducible with clarithromycin and the ketolide HMR3004. Furthermore, underlying the phenotypic induction was an increase in erm(37) mRNA levels.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Clarithromycin / pharmacology
  • Drug Resistance, Bacterial*
  • Gene Expression Regulation, Bacterial*
  • Humans
  • Ketolides / pharmacology
  • Macrolides / pharmacology*
  • Methyltransferases / genetics
  • Methyltransferases / metabolism*
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Ketolides
  • Macrolides
  • Methyltransferases
  • Clarithromycin