Binding and production of insulin-like growth factor-I in rat mammary gland

S Lavandero; J F Santibáñez; M P Ocaranza; A Ferreira; M Sapag-Hagar

doi:10.1016/0300-9629(91)90123-t

Binding and production of insulin-like growth factor-I in rat mammary gland

Comp Biochem Physiol A Comp Physiol. 1991;99(4):507-11. doi: 10.1016/0300-9629(91)90123-t.

Authors

S Lavandero¹, J F Santibáñez, M P Ocaranza, A Ferreira, M Sapag-Hagar

Affiliation

¹ Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago.

PMID: 1679688
DOI: 10.1016/0300-9629(91)90123-t

Abstract

1. Mammary tissue from pregnant rat presents low and high affinity IGF-I functional receptors. 2. Mammary explants from pregnant and lactating rats secrete IGF-I and its production was related to the developmental stage of the gland. 3. An inverse relationship between IGF-I production and tissue binding capacity was observed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Binding, Competitive
Female
Insulin-Like Growth Factor I / metabolism*
Kinetics
Mammary Glands, Animal / metabolism*
Organ Culture Techniques
Pregnancy
Radioimmunoassay
Rats
Rats, Inbred Strains
Temperature

Substances

Insulin-Like Growth Factor I