Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation

Benjamin E Blass; Keith Coburn; Wenlin Lee; Neil Fairweather; Andrew Fluxe; Shengde Wu; John M Janusz; Michael Murawsky; Gina M Fadayel; Bin Fang; Michelle Hare; Jim Ridgeway; Ron White; Chris Jackson; Laurent Djandjighian; Richard Hedges; Fred C Wireko; Amanda L Ritter

doi:10.1016/j.bmcl.2006.06.001

Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4629-32. doi: 10.1016/j.bmcl.2006.06.001. Epub 2006 Jun 21.

Authors

Benjamin E Blass¹, Keith Coburn, Wenlin Lee, Neil Fairweather, Andrew Fluxe, Shengde Wu, John M Janusz, Michael Murawsky, Gina M Fadayel, Bin Fang, Michelle Hare, Jim Ridgeway, Ron White, Chris Jackson, Laurent Djandjighian, Richard Hedges, Fred C Wireko, Amanda L Ritter

Affiliation

¹ Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. bblass2@fuse.net

PMID: 16793267
DOI: 10.1016/j.bmcl.2006.06.001

Abstract

A series of novel (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones were prepared and examined for utility as Kv1.5 channel blockers for the treatment of atrial fibrillation.

MeSH terms

Atrial Fibrillation / metabolism*
Cell Line
Crystallography, X-Ray
Humans
Kv1.5 Potassium Channel / antagonists & inhibitors*
Kv1.5 Potassium Channel / metabolism*
Methane / chemical synthesis
Methane / chemistry*
Methane / pharmacology*
Models, Molecular
Molecular Structure
Potassium Channel Blockers / chemical synthesis*
Potassium Channel Blockers / chemistry
Potassium Channel Blockers / pharmacology*
Structure-Activity Relationship

Substances

Kv1.5 Potassium Channel
Potassium Channel Blockers
Methane