An expedient synthesis of N6-substituted-5'-modified adenosines

T D Ashton; Peter J Scammells

doi:10.1016/j.bmcl.2006.06.019

An expedient synthesis of N6-substituted-5'-modified adenosines

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4564-6. doi: 10.1016/j.bmcl.2006.06.019. Epub 2006 Jun 21.

Authors

T D Ashton¹, Peter J Scammells

Affiliation

¹ Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, Parkville, Vic., Australia.

PMID: 16793263
DOI: 10.1016/j.bmcl.2006.06.019

Abstract

Herein we report a short and efficient synthesis of N(6)-substituted 5'-modified adenosines, which was achieved in four steps from 2',3',5'-tris-O-(tert-butyldimethylsilyl)inosine.

MeSH terms

Adenosine / chemical synthesis
Adenosine / chemistry*
Inosine / chemistry
Molecular Structure

Substances

Inosine
Adenosine