Donor cell leukemia developing after hematopoietic stem cell transplantation for multiple myeloma

V Havelange; H Antoine-Poirel; P Saussoy; E Van Den Neste; A Ferrant

doi:10.1179/acb.2006.016

Donor cell leukemia developing after hematopoietic stem cell transplantation for multiple myeloma

Acta Clin Belg. 2006 Mar-Apr;61(2):82-6. doi: 10.1179/acb.2006.016.

Authors

V Havelange¹, H Antoine-Poirel, P Saussoy, E Van Den Neste, A Ferrant

Affiliation

¹ Service d'Hématologie, Centre de Génétique, Secteur Hématologie, Cliniques universitaires Saint-Luc, 1200 Bruxelles.

PMID: 16792340
DOI: 10.1179/acb.2006.016

Abstract

The development of secondary leukemia in donor cells after allogeneic stem cell transplantation is a rare event. We describe the occurrence of acute myeloid leukemia in donor cells 4 years after a stem cell transplantation for multiple myeloma. The multiple myeloma was relapsing at the time of the onset of acute myeloid leukemia. Secondary leukemia in donor cells after transplantation for multiple myeloma has not yet been reported.

Publication types

Case Reports

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Cytarabine / administration & dosage
Follow-Up Studies
Hematopoietic Stem Cell Transplantation / adverse effects*
Hematopoietic Stem Cell Transplantation / methods
Humans
Idarubicin / administration & dosage
In Situ Hybridization, Fluorescence
Leukemia, Myeloid, Acute / drug therapy*
Leukemia, Myeloid, Acute / etiology*
Leukemia, Myeloid, Acute / pathology
Living Donors*
Male
Multiple Myeloma / diagnosis
Multiple Myeloma / therapy*
Recurrence
Remission Induction
Risk Assessment
Severity of Illness Index
Treatment Outcome

Substances

Cytarabine
Idarubicin