The oxygen flow modulator is a device for percutaneous transtracheal emergency ventilation. Simulating a respiratory arrest situation, we studied the effects of this device in comparison with a hand-triggered emergency jet injector during pulmonary resuscitation. Nine pigs were anesthetized and mechanically ventilated. After surgical exposure, an emergency transtracheal airway catheter was inserted into the trachea. Ventilation was stopped until SpO2 was below 70%. Each animal was subsequently randomly ventilated via the transtracheal airway catheter with either the hand-triggered emergency jet injector or the oxygen flow modulator. After 10 minutes, respiratory and hemodynamic parameters were recorded. Ventilation was stopped again until SpO2 reached 70%, and the animal was ventilated with the second device. With both devices, pulmonary resuscitation was successful. Whereas PaO2 differed not significantly between the two devices, PaCO2 was lower during percutaneous transtracheal ventilation with the hand-triggered emergency jet injector.