High affinity inhibitors of the dopamine transporter (DAT): novel biotinylated ligands for conjugation to quantum dots

Ian D Tomlinson; John N Mason; Randy D Blakely; Sandra J Rosenthal

doi:10.1016/j.bmcl.2006.05.097

High affinity inhibitors of the dopamine transporter (DAT): novel biotinylated ligands for conjugation to quantum dots

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4664-7. doi: 10.1016/j.bmcl.2006.05.097. Epub 2006 Jun 19.

Authors

Ian D Tomlinson¹, John N Mason, Randy D Blakely, Sandra J Rosenthal

Affiliation

¹ The Department of Chemistry, Vanderbilt University, Nashville, TN 37235-1822, USA. iand@femto.cas.vanderbilt.edu

PMID: 16784853
DOI: 10.1016/j.bmcl.2006.05.097

Abstract

Compounds capable of inhibiting the dopamine transporter protein (DAT) that can be conjugated to cadmium selenide/zinc sulfide/core shell nanocrystals may be used to image the location and distribution of the DAT in neuronal cell membranes. This letter describes the synthesis of biotinylated analogs of the DAT antagonists GBR 12909 and GBR 12935 that can be attached to streptavidin coated cadmium selenide/zinc sulfide/core shell nanocrystals.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Biotinylation
Dopamine / metabolism
Dopamine Plasma Membrane Transport Proteins / antagonists & inhibitors*
Dopamine Plasma Membrane Transport Proteins / metabolism
Humans
Inhibitory Concentration 50
Ligands
Molecular Structure
Quantum Dots*

Substances

Dopamine Plasma Membrane Transport Proteins
Ligands
Dopamine

Abstract

Publication types

MeSH terms

Substances

Grants and funding