This paper provides a conceptual, theoretical, and empirical overview of the concept of the transcendent experience. The principal goal is to formalize a scientific field around the study of dimensions, determinants, and health outcomes of transcendence. This is accomplished through posing several fundamental questions and then answering them as concisely as possible in light of current theory and existing empirical research. These include the following: "What is the transcendent experience?" "Can the transcendent experience be studied?" "What do we (and don't we) know about the transcendent experience?" "How is the transcendent experience triggered?" "How is the transcendent experience sustained?" "Are there physiological models of the transcendent experience?" "Are there health effects of the transcendent experience?" and, "How should we study the health effects of the transcendent experience?" Finally, an agenda is proposed for research on the role of the transcendent experience in health, emphasizing development of an epidemiology of the transcendent experience.