The simplest method is introduced for reliable estimating the detonation velocity of large class of CHNO explosives based elemental composition and specific structural groups. There is no need to use heat of formation and the other experimental data for calculation of detonation velocity in the new procedure. Only elemental composition and the number of special structural groups without using heat of formation of explosive is sufficient for reliable desk calculation of detonation velocity. The results show good agreement with experimental values with respect to computed results obtained by complex computer code using BKWS and BKWR equations of state. Predicted velocities of detonation have root-mean-square (rms) percent deviation of 2.2, 5.9 and 5.3 from experimental data for new method, BKWS and BKWR equations of state, respectively.