Musashi1 antigen expression in human fetal germinal matrix development

Exp Neurol. 2006 Oct;201(2):515-8. doi: 10.1016/j.expneurol.2006.04.023. Epub 2006 Jun 14.

Abstract

Musashi1 is a highly conserved protein found in neural progenitor cells. We examined the expression dynamics of Musashi1 in conjunction with other representative neural progenitor antigenic determinants (Ki-67 and nestin) during 8 different stages of the developing human fetal germinal matrix. Our results indicate that Musashi1 is a useful marker for immature cells in periventricular areas inhabited by stem cells, progenitor cells, and differentiating cells.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Brain / embryology*
  • Brain Chemistry*
  • Cerebral Ventricles / chemistry
  • Cerebral Ventricles / embryology
  • Fetal Development
  • Gestational Age
  • Glial Fibrillary Acidic Protein / analysis
  • Humans
  • Immunohistochemistry
  • Intermediate Filament Proteins / analysis
  • Ki-67 Antigen / analysis
  • Nerve Tissue Proteins / analysis
  • Nerve Tissue Proteins / biosynthesis*
  • Nestin
  • RNA-Binding Proteins / biosynthesis*

Substances

  • Glial Fibrillary Acidic Protein
  • Intermediate Filament Proteins
  • Ki-67 Antigen
  • MSI1 protein, human
  • NES protein, human
  • Nerve Tissue Proteins
  • Nestin
  • RNA-Binding Proteins