Ignoring endotoxin

J Exp Med. 2006 May 15;203(5):1137. doi: 10.1084/jem.2035fta.

Abstract

In 1947, Paul Beeson showed that rabbits repeatedly injected with certain bacteria eventually become resistant to the bacteria's fever-provoking effects-a phenomenon known as endotoxin tolerance.

Publication types

  • Biography
  • Historical Article
  • Portrait

MeSH terms

  • Animals
  • Gram-Negative Bacteria / immunology*
  • History, 20th Century
  • Humans
  • Immune Tolerance*
  • Inflammation / chemically induced
  • Inflammation / history
  • Inflammation / immunology
  • Lipopolysaccharides / history
  • Lipopolysaccharides / immunology*
  • Lipopolysaccharides / therapeutic use
  • Neoplasms / history
  • Neoplasms / immunology
  • Neoplasms / therapy
  • Rabbits

Substances

  • Lipopolysaccharides

Personal name as subject

  • Paul Beeson