Effects of ginsenoside-Rb2 on adenine nucleotide content of rat hepatic tissue

J Pharm Pharmacol. 1991 Apr;43(4):290-1. doi: 10.1111/j.2042-7158.1991.tb06689.x.

Abstract

In comparison with non-diabetic rats, the tissue ATP content of diabetic rats is lower and the AMP content higher. However, daily intraperitoneal administration of ginsenoside-Rb2 for several days resulted in an increase of tissue ATP content and a decrease of AMP content, characterized by an increase in the adenine nucleotide content, as well as improvement of energy charge. Thus, ginsenoside-Rb2 administration caused a change in the pattern of metabolism, activating the ATP supply system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine Nucleotides / metabolism*
  • Adenosine Diphosphate / metabolism
  • Adenosine Monophosphate / metabolism
  • Adenosine Triphosphate / metabolism
  • Animals
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Experimental / metabolism
  • Ginsenosides*
  • Hypolipidemic Agents / pharmacology*
  • Liver / drug effects
  • Liver / metabolism*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Saponins / pharmacology*

Substances

  • Adenine Nucleotides
  • Blood Glucose
  • Ginsenosides
  • Hypolipidemic Agents
  • Saponins
  • ginsenoside Rb2
  • Adenosine Monophosphate
  • Adenosine Diphosphate
  • Adenosine Triphosphate