Abstract
In comparison with non-diabetic rats, the tissue ATP content of diabetic rats is lower and the AMP content higher. However, daily intraperitoneal administration of ginsenoside-Rb2 for several days resulted in an increase of tissue ATP content and a decrease of AMP content, characterized by an increase in the adenine nucleotide content, as well as improvement of energy charge. Thus, ginsenoside-Rb2 administration caused a change in the pattern of metabolism, activating the ATP supply system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine Nucleotides / metabolism*
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Adenosine Diphosphate / metabolism
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Adenosine Monophosphate / metabolism
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Adenosine Triphosphate / metabolism
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Animals
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Blood Glucose / metabolism
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Diabetes Mellitus, Experimental / metabolism
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Ginsenosides*
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Hypolipidemic Agents / pharmacology*
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Liver / drug effects
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Liver / metabolism*
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Male
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Rats
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Rats, Inbred Strains
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Saponins / pharmacology*
Substances
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Adenine Nucleotides
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Blood Glucose
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Ginsenosides
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Hypolipidemic Agents
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Saponins
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ginsenoside Rb2
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Adenosine Monophosphate
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Adenosine Diphosphate
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Adenosine Triphosphate