[Progress in mechanism of microcystin toxicity]

Wen-yu Fu; Li-hong Xu

doi:10.3785/j.issn.1008-9292.2006.03.021

[Progress in mechanism of microcystin toxicity]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 May;35(3):342-6. doi: 10.3785/j.issn.1008-9292.2006.03.021.

[Article in Chinese]

Authors

Wen-yu Fu¹, Li-hong Xu

Affiliation

¹ Department of Biochemistry and Molecular Biology, Institute of Occupational and Environmental Health, College of Medicine, Zhejiang University, Hangzhou 310031, China.

PMID: 16764042
DOI: 10.3785/j.issn.1008-9292.2006.03.021

Abstract

Microcystin is one of the monocyclic heptapeptides produced primarily by microcystis aeruginosa. Recent studies suggest that microcystin can induce cell apoptosis, as well as oxidative stress and mitochondrial alteration. Studies also indicate that Bcl-2 family and p53 may play an important role in the apoptosis induced by microcystin.

Publication types

English Abstract
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Apoptosis / physiology*
Humans
Microcystins / toxicity*
Microcystis / metabolism
Proto-Oncogene Proteins c-bcl-2 / metabolism*
Tumor Suppressor Protein p53 / metabolism*

Substances

Microcystins
Proto-Oncogene Proteins c-bcl-2
Tumor Suppressor Protein p53
microcystin