[A case of inflammatory myofibroblastic tumor of the urinary bladder finally diagnosed by anaplastic lymphoma kinase (ALK) immunostaining]

Hinyokika Kiyo. 2006 May;52(5):375-8.
[Article in Japanese]

Abstract

A 52-year-old house wife presented with pain on urination. Cystoscopy and magnetic resonance imaging revealed solid and sessile tumor of 3 cm in diameter invading the bladder wall. Pathological examination of the transurethral resection specimen showed proliferation of spindle cells and epithelial cells. Since both types of cells were positive for cytokeratin immunostaining, sarcomatoid carcinoma was highly suspected. She underwent anterior pelvic exenteration and construction of continent reservoir (Penn Pouch). Since the tumor cells showed spindle cell proliferation alone without epithelial growth and positive staining for anaplastic lymphoma kinase, we corrected the final diagnosis as an inflammatory myofibroblastic tumor of the urinary bladder. She has been doing well without recurrence for 1 year.

Publication types

  • Case Reports

MeSH terms

  • Anaplastic Lymphoma Kinase
  • Cystoscopy
  • Diagnosis, Differential
  • Female
  • Granuloma, Plasma Cell / pathology*
  • Granuloma, Plasma Cell / surgery
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Pelvic Exenteration
  • Protein-Tyrosine Kinases / analysis*
  • Receptor Protein-Tyrosine Kinases
  • Urinary Bladder Neoplasms / pathology*
  • Urinary Bladder Neoplasms / surgery

Substances

  • ALK protein, human
  • Anaplastic Lymphoma Kinase
  • Protein-Tyrosine Kinases
  • Receptor Protein-Tyrosine Kinases