Synthesis and analgesic activity of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides

Biol Pharm Bull. 2006 Jun;29(6):1180-5. doi: 10.1248/bpb.29.1180.

Abstract

A series of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides were synthesized and evaluated for their analgesic activities. Several compounds were significantly more potent than mefenamic acid and diclofenac sodium in abdominal constriction and formalin tests.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Hydrazines / chemical synthesis*
  • Hydrazines / chemistry
  • Hydrazines / pharmacology*
  • Hydrazines / therapeutic use
  • Male
  • Mice
  • Molecular Structure
  • Pain / drug therapy
  • Pain Measurement
  • Structure-Activity Relationship
  • ortho-Aminobenzoates / chemistry*
  • ortho-Aminobenzoates / pharmacology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Hydrazines
  • ortho-Aminobenzoates
  • fenamic acid