The FIP1L1-PDGFRA T674I mutation can be inhibited by the tyrosine kinase inhibitor AMN107 (nilotinib)

MeSH terms

• Amino Acid Substitution*
• Benzamides
• Cells, Cultured
• Humans
• Hypereosinophilic Syndrome / drug therapy
• Hypereosinophilic Syndrome / enzymology*
• Imatinib Mesylate
• Oncogene Proteins, Fusion / antagonists & inhibitors*
• Oncogene Proteins, Fusion / genetics
• Piperazines / therapeutic use
• Point Mutation*
• Protein Kinase Inhibitors / pharmacology*
• Protein Kinase Inhibitors / therapeutic use
• Pyrimidines / pharmacology*
• Pyrimidines / therapeutic use
• Receptor, Platelet-Derived Growth Factor alpha / antagonists & inhibitors*
• Receptor, Platelet-Derived Growth Factor alpha / genetics
• mRNA Cleavage and Polyadenylation Factors / antagonists & inhibitors*
• mRNA Cleavage and Polyadenylation Factors / genetics