Suicide rates and antidepressant prescribing: a casual or causal relationship?

PLoS Med. 2006 Jun;3(6):e220. doi: 10.1371/journal.pmed.0030220.

Abstract

Baune and Hay discuss the strengths and limitations of an ecological study that found an inverse correlation between suicide rates and fluoxetine prescriptions.

MeSH terms

  • Adolescent
  • Adult
  • Antidepressive Agents, Second-Generation / administration & dosage
  • Antidepressive Agents, Second-Generation / adverse effects*
  • Depression / drug therapy*
  • Female
  • Fluoxetine / administration & dosage
  • Fluoxetine / adverse effects*
  • Humans
  • Male
  • Research Design
  • Selective Serotonin Reuptake Inhibitors / administration & dosage
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Suicide / statistics & numerical data*
  • Suicide / trends
  • United States

Substances

  • Antidepressive Agents, Second-Generation
  • Serotonin Uptake Inhibitors
  • Fluoxetine