Influence of triglycerides on other plasma lipids in middle-aged men intended for hypolipidaemic treatment

Hellenic J Cardiol. 2006 Mar-Apr;47(2):78-83.

Abstract

Introduction: The present investigation aimed to evaluate the influence of serum triglycerides (TG) on other plasma lipids in male patients less than 65 years of age intended for hypolipidaemic treatment.

Methods: Lipid profiles of a cohort of 412 dyslipidaemic male patients aged 53.4 +/- 7.7 years (mean +/- standard deviation) were evaluated. Patients were stratified in accordance with their fasting plasma lipid levels. They were divided into multiple groups on the basis of serum TG (> or = 150 or < 150 mg/dl) and high-density lipoprotein cholesterol (HDL-C > or = 40 or < 40 mg/dl).

Results: Patients with TG > or = 150 mg/dl had higher total cholesterol and lower HDL-C levels compared with those with TG < 150 mg/dl (p = 0.005 and p < 0.001, respectively). Patients with HDL-C < 40 mg/dl had similar total cholesterol levels and higher TG levels compared to those with HDL-C > or = 40 mg/dl (p < 0.001). In all patients, an inverse correlation between TG and HDL-C was found (r = -0.286, p < 0.001). Additionally, HDL-C levels were inversely correlated with the TG concentration in patients with TG < 150 mg/dl (r = -0.135, p = 0.042) and TG > or = 150 mg/dl (r = -0.188, p = 0.002).

Conclusions: An inverse correlation between TG and HDL-C levels seems to exist in the sampled population, revealing a close link between the metabolic pathways for TG and HDL-C. This inverse correlation appears to persist even in patients with low fasting TG levels.

Publication types

  • Comparative Study

MeSH terms

  • Biomarkers / blood
  • Cholesterol / blood
  • Cholesterol, HDL / blood*
  • Follow-Up Studies
  • Humans
  • Hyperlipidemias / blood*
  • Hyperlipidemias / drug therapy
  • Hypolipidemic Agents / therapeutic use*
  • Male
  • Middle Aged
  • Prognosis
  • Triglycerides / blood*

Substances

  • Biomarkers
  • Cholesterol, HDL
  • Hypolipidemic Agents
  • Triglycerides
  • Cholesterol