Structure and stereochemistry of brianolide, a new antiinflammatory diterpenoid from the Okinawan gorgonian Briareum sp

J Kobayashi; J F Cheng; H Nakamura; Y Ohizumi; Y Tomotake; T Matsuzaki; K J Grace; R S Jacobs; Y Kato; L S Brinen

doi:10.1007/BF01959955

Structure and stereochemistry of brianolide, a new antiinflammatory diterpenoid from the Okinawan gorgonian Briareum sp

Experientia. 1991 May 15;47(5):501-2. doi: 10.1007/BF01959955.

Authors

J Kobayashi¹, J F Cheng, H Nakamura, Y Ohizumi, Y Tomotake, T Matsuzaki, K J Grace, R S Jacobs, Y Kato, L S Brinen, et al.

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

PMID: 1675176
DOI: 10.1007/BF01959955

Abstract

Brianolide (1), a new antiinflammatory diterpenoid of the briarein class, possessing a beta substituent at C-12 (R), has been isolated from the Okinawan gorgonian Briareum sp. Its structure has been established from spectral data in conjunction with a single crystal X-ray analysis.

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / chemistry*
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
Cnidaria*
Diterpenes / chemistry*
Diterpenes / isolation & purification
Magnetic Resonance Spectroscopy
Molecular Conformation

Substances

Anti-Inflammatory Agents, Non-Steroidal
Diterpenes
brianolide