Abstract
West Nile virus (WNV) infects thousands of humans annually and causes a spectrum of disease ranging from an acute febrile illness to lethal encephalitis. A new study suggests a link between CCR5Delta32 (a common mutant allele of the chemokine and HIV receptor CCR5) and fatal WNV infection. The study highlights a possible risk in targeting this receptor for the prevention and/or treatment of infectious diseases.
MeSH terms
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Alleles
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Animals
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Chemokine CCL5
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Chemokine CXCL10
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Chemokines, CC / immunology
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Chemokines, CXC / immunology
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Genetic Predisposition to Disease*
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Humans
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Mice
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Mutation
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Receptors, CCR5 / genetics*
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Receptors, CCR5 / immunology
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Risk Factors
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West Nile Fever / epidemiology
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West Nile Fever / genetics*
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West Nile Fever / virology
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West Nile virus / pathogenicity
Substances
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Ccl5 protein, mouse
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Chemokine CCL5
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Chemokine CXCL10
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Chemokines, CC
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Chemokines, CXC
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Cxcl10 protein, mouse
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Receptors, CCR5