Convenient method of synthesizing 3-ethoxycarbonyl indoles

J Org Chem. 2006 Jun 9;71(12):4675-7. doi: 10.1021/jo0601821.

Abstract

We have developed a convenient two-step procedure for the synthesis of 3-ethoxycarbonyl indoles from commercially available materials. The two-step procedure involves the synthesis of 2-aryl-3-hydroxypropenoic acid ester, followed by a catalytic reduction. This method is efficient, simple, and selective.

MeSH terms

  • Catalysis
  • Hydrogenation
  • Indoles / chemical synthesis*
  • Methods

Substances

  • Indoles