Aspergillus infection is invasive in nature in the immunosuppressed population and disseminates throughout the body, with the brain being a common site. Conventional magnetic resonance imaging (MRI) combined with diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) play a life-saving role in the early diagnosis and treatment monitoring of this potentially fatal infection. We present MRI, DWI, and MRS findings of a case of central nervous system aspergillosis with treatment follow-up.