Abstract
We describe 3 patients who presented with features of macrophage activation syndrome (MAS) at the time of presentation of systemic lupus erythematosus (SLE), systemic juvenile idiopathic arthritis, and Kawasaki disease. Immunohistochemical studies in the patient with SLE demonstrated extensive expression of CD163 on hemophagocytic macrophages, suggesting a possible role as a marker of MAS.
MeSH terms
-
Adolescent
-
Antigens, CD / metabolism
-
Antigens, Differentiation, Myelomonocytic / metabolism
-
Arthritis, Juvenile / complications*
-
Arthritis, Juvenile / immunology
-
Arthritis, Juvenile / metabolism
-
Female
-
Humans
-
Infant
-
Lupus Erythematosus, Systemic / complications*
-
Lupus Erythematosus, Systemic / immunology
-
Lupus Erythematosus, Systemic / metabolism
-
Macrophage Activation*
-
Male
-
Mucocutaneous Lymph Node Syndrome / complications*
-
Mucocutaneous Lymph Node Syndrome / immunology
-
Mucocutaneous Lymph Node Syndrome / metabolism
-
Receptors, Cell Surface / metabolism
-
Syndrome
Substances
-
Antigens, CD
-
Antigens, Differentiation, Myelomonocytic
-
CD163 antigen
-
Receptors, Cell Surface