Trends in antipsychotic prescribing in schizophrenia in Auckland

Australas Psychiatry. 2006 Jun;14(2):169-74. doi: 10.1080/j.1440-1665.2006.02273.x.

Abstract

Objective: This study describes antipsychotic prescribing practices for outpatients with schizophrenia over a 3 year period in two large mental health catchment areas of Auckland.

Methods: All community files were reviewed at three time points. Patient characteristics, diagnosis and antipsychotic treatment information were recorded and analysed.

Results: Over the three time periods, the number of outpatients with a diagnosis of schizophrenia or schizoaffective disorder was stable. There was a marked change in the type of antipsychotic prescribed, with an 18.6% increase in atypical antipsychotics and a decrease in both intramuscular and oral typical antipsychotics. Clozapine was the most commonly prescribed antipsychotic in 2003 (35%). Despite the fact that polypharmacy was relatively low (14.6% in 2003), those receiving more than one antipsychotic had a greater likelihood of being prescribed a higher total daily dose.

Conclusions: This study describes a change in antipsychotic prescribing towards recommended practice guidelines for the treatment of schizophrenia over a 3 year period.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Ambulatory Care / trends
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use*
  • Delayed-Action Preparations
  • Dose-Response Relationship, Drug
  • Drug Prescriptions / statistics & numerical data*
  • Drug Therapy, Combination
  • Drug Utilization / trends
  • Female
  • Humans
  • Injections, Intramuscular
  • Male
  • New Zealand
  • Retrospective Studies
  • Schizophrenia / drug therapy*
  • Schizophrenia / epidemiology
  • Urban Population / statistics & numerical data*

Substances

  • Antipsychotic Agents
  • Delayed-Action Preparations