Abstract
Two novel polymers of low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-beta-cyclodextrin or (2-hydroxypropyl)-gamma-cyclodextrin showed lower cytotoxicity and higher transfection efficiency for the delivery of plasmid DNA compared with those of polyethylenimine (PEI, 25 kDa).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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2-Hydroxypropyl-beta-cyclodextrin
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Cell Line, Tumor
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Cell Survival / drug effects
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Cross-Linking Reagents / chemical synthesis*
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Cross-Linking Reagents / chemistry
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Cross-Linking Reagents / pharmacology
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DNA / drug effects
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Drug Screening Assays, Antitumor
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Gene Transfer Techniques*
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Genetic Vectors / chemical synthesis*
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Genetic Vectors / chemistry
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Genetic Vectors / pharmacology
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Humans
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Molecular Structure
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Molecular Weight
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Polyethyleneimine / chemistry*
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Structure-Activity Relationship
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beta-Cyclodextrins / chemistry*
Substances
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Cross-Linking Reagents
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beta-Cyclodextrins
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2-Hydroxypropyl-beta-cyclodextrin
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Polyethyleneimine
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DNA