Two novel non-viral gene delivery vectors: low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-beta-cyclodextrin or (2-hydroxypropyl)-gamma-cyclodextrin

Chem Commun (Camb). 2006 Jun 14:(22):2382-4. doi: 10.1039/b601130f. Epub 2006 Mar 22.

Abstract

Two novel polymers of low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-beta-cyclodextrin or (2-hydroxypropyl)-gamma-cyclodextrin showed lower cytotoxicity and higher transfection efficiency for the delivery of plasmid DNA compared with those of polyethylenimine (PEI, 25 kDa).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Hydroxypropyl-beta-cyclodextrin
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cross-Linking Reagents / chemical synthesis*
  • Cross-Linking Reagents / chemistry
  • Cross-Linking Reagents / pharmacology
  • DNA / drug effects
  • Drug Screening Assays, Antitumor
  • Gene Transfer Techniques*
  • Genetic Vectors / chemical synthesis*
  • Genetic Vectors / chemistry
  • Genetic Vectors / pharmacology
  • Humans
  • Molecular Structure
  • Molecular Weight
  • Polyethyleneimine / chemistry*
  • Structure-Activity Relationship
  • beta-Cyclodextrins / chemistry*

Substances

  • Cross-Linking Reagents
  • beta-Cyclodextrins
  • 2-Hydroxypropyl-beta-cyclodextrin
  • Polyethyleneimine
  • DNA