Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues

Chem Commun (Camb). 2006 Jun 14:(22):2341-3. doi: 10.1039/b602931k. Epub 2006 May 11.

Authors

Steven J Moss¹, Isabelle Carletti, Carlos Olano, Rose M Sheridan, Michael Ward, Vidya Math, Mohammad Nur-E-Alam, Alfredo F Braña, Ming Qiang Zhang, Peter F Leadlay, Carmen Méndez, José A Salas, Barrie Wilkinson

Affiliation

¹ Biotica, Chesterford Research Park, Little Chesterford, UK CB10 1XL.

PMID: 16733573
DOI: 10.1039/b602931k

Abstract

We report the directed biosynthesis of borrelidin analogues and their selective anti-proliferative activity against human cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiogenesis Inhibitors / biosynthesis*
Angiogenesis Inhibitors / chemistry
Angiogenesis Inhibitors / pharmacology
Cell Line, Tumor
Cell Survival
Drug Screening Assays, Antitumor
Fatty Alcohols / chemistry
Fatty Alcohols / metabolism
Fatty Alcohols / pharmacology
Humans
Molecular Conformation
Neoplasms / drug therapy*
Stereoisomerism

Substances

Angiogenesis Inhibitors
Fatty Alcohols
borrelidin