Hypersexuality and paraphilia induced by selegiline in Parkinson's disease: report of 2 cases

Parkinsonism Relat Disord. 2006 Sep;12(6):392-5. doi: 10.1016/j.parkreldis.2006.01.010. Epub 2006 May 26.

Abstract

While hypersexuality and paraphilia are known side effects of anti-Parkinson medications, it is seldom reported. Furthermore, selegiline is rarely implicated in such behaviors. We report two cases of early onset PD who experienced paraphilia and hypersexuality when selegiline was initiated, and later developing obsessive-compulsive and punding behavior with the addition of dopamine agonists. Social repercussions may prohibit patients and/or their families from volunteering such information.

Publication types

  • Case Reports

MeSH terms

  • Antiparkinson Agents / adverse effects*
  • Antiparkinson Agents / therapeutic use
  • Compulsive Behavior / chemically induced
  • Compulsive Behavior / psychology
  • Erotica
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Parkinson Disease / complications*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / psychology
  • Personality Disorders / chemically induced
  • Personality Disorders / psychology
  • Psychiatric Status Rating Scales
  • Selegiline / adverse effects*
  • Selegiline / therapeutic use
  • Sexual Dysfunctions, Psychological / chemically induced*
  • Sexual Dysfunctions, Psychological / psychology

Substances

  • Antiparkinson Agents
  • Selegiline