Abstract
Bromophycolides C-I (1-7) were isolated from extracts of the Fijian red alga Callophycus serratus and identified by NMR and mass spectral techniques. These novel natural products share a carbon skeleton and biosynthetic origin with previously identified bromophycolides A (8) and B (9), which form a rare group of diterpene-benzoate macrolides. Bromophycolides C-I (1-7) displayed modest antineoplastic activity against a range of human tumor cell lines.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Fiji
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Humans
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Rhodophyta / chemistry*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Diterpenes
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Macrolides